Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region

Jornal Brasileiro de Patologia e Medicina Laboratorial

Eliane Soler Parra²  Vanessa Helena De Souza Zago¹  Natália Baratella Panzoldo¹  Fernanda Alexandre¹  Felipe Vendrame¹  Vitor Wilson De Moura Virginio¹  Isabela Calanca Vieira¹  Marcelo Scarpari Dutra Rodrigues¹  Angela De Souza Cassol¹  Fabio D'alexandri¹  Vera Sylvia Castanho¹  Rui Nakamura¹  Jamal Baracat¹  Mirian Regina Gardin Danelon¹  Ronise Carla Sass Pozeti¹  Ana Cândida Coutinho Facin¹  Hilda Maria Da Silva Honorio¹  Simone De Cássia Dias Mesquita¹  Marcio Jorge Da Silva¹  Marielza Crosgnac Feres Lot¹  Valéria Sutti Nunes¹  Camila Canteiro Leança¹  Edna Regina Nakandakare¹  Eder Carlos Rocha Quintão¹  Eliana Cotta De Faria¹ 

[1] ,Universidade Estadual de Campinas Faculdade de Ciências Médicas Clinical Medicine

关键词: health institutes;    HDL-C;    data collection;    instituições de saúde;    HDL-C;    coleta de dados;   

DOI  :  10.1590/S1676-24442013000100004

来源: SciELO

【 摘 要 】

INTRODUCTION: The development of research for diagnosis, prevention and treatment of atherosclerotic cardiovascular disease is of utmost importance due to the fact that it is the main cause of morbidity and mortality in Brazil. OBJECTIVE: To demonstrate the phases of the selection process for candidates with the aim to develop a clinical-laboratorial database of hyper alpha lipoproteinemic patients (hyper A) - high density lipoprotein cholesterol (HDL-C) ≥ 68 mg/dl) and hypo alpha lipoproteinemic patients (hypo A) - HDL-C < 39 mg/dl. MATERIAL AND METHODS: The volunteers were contacted after selection of lipid profiles from individuals treated at the Sistema Único de Saúde (SUS), Campinas-SP and neighboring area. Afterwards, the selected patients went through blood collection, clinical examinations and answered questionnaires on dietary frequency and physical activity. After this preliminary evaluation, some individuals were convened to another blood collection and, subsequently, were submitted to an ultrasonographic exam of the carotid arteries. RESULTS: Only 0.6% and 0.3% from 598,288 lipid profiles were selected for hyper A and hypo A groups, respectively, including gender disparity. Lack of effective questionnaires (75%), missing calls (60%) and non-inclusion were the major hindrances in the construction of this database. DISCUSSION: The difficulties to obtain eligible candidates were also due to the low prevalence of both groups hypo A and hyper A and the high prevalence of pathologies that contribute to non-genetic variations of HDL-C. CONCLUSION: In spite of the obstacles in the development of this database, this study brought about several scientific publications. Furthermore, the development of molecular analyzes and functionality will shortly generate other findings, contributing to the diagnosis and follow-up of HDL dyslipidemias.

【 授权许可】

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