Analysis of the association between Epstein-Barr virus and classic Hodgkin’s lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization

Jornal Brasileiro de Patologia e Medicina Laboratorial

Marília Taumaturgo Pinto²  Francisco Valdeci De Almeida Ferreira¹  Maria Da Silva Pitombeira¹  Silvia Maria Meira Magalhães¹  Clara Maria Bastos Eloy Da Costa¹  Paulo Wagner Linhares Lima Filho¹  Renata Praciano Correia Férrer¹  Andrei Levine Porfírio De Aguiar¹  Francisco Dário Rocha Filho¹ 

[1],Universidade Estadual do Ceará Pathology Department

关键词: Classical Hodgkin’s lymphoma;    Epstein-Barr virus;    LMP1;    EBER1;    Linfoma de Hodgkin clássico;    Vírus Epstein-Barr;    LMP1;    EBER1;   

DOI  :  10.1590/S1676-24442006000300009

来源: SciELO

【 摘 要 】

The prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkin’s lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66).

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