Recombinant human erythropoietin in sports: a review

Revista Brasileira de Medicina do Esporte

Rafael Maia De Almeida Bento¹  Lúcia Menezes Pinto Damasceno¹  Francisco Radler De Aquino Neto¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Química Laboratório de Controle de DopagemRio de Janeiro RJ ,Brasil

关键词: Erythropoietin;    Epoetin;    Peptidic hormones;    Doping control;   

DOI  :  10.1590/S1517-86922003000300006

来源: SciELO

【 摘 要 】

Erythropoietin is an endogenous hormone of glicoproteic nature secreted by the kidneys and is the main regulator of the erythropoiesis. An alteration in its production generates a disturbance in the plasmatic concentration giving rise to several types of pathologies related to the hematopoietic system. The recombinant forms of erythropoietin have indiscriminately been used by athletes, mainly in endurance sports, by increasing the erythrocytes concentration, generating a better delivery of oxygen to the muscle tissue. The administration of recombinant erythropoietin was prohibited by the International Olympic Committee and its use considered as doping. This review has the intention to describe the physical, biological and pharmacokinetic properties of the endogenous erythropoietin, as well as its recombinant form, describing also its use in sports and the process of searching methodologies for its detection in doping control.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License