Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile

Brazilian Journal of Microbiology

Paulo Murillo Neufeld¹  Marcia De Souza Carvalho Melhem¹  Maria Walderez Szeszs¹  Marcos Dornelas Ribeiro¹  Efigênia De Lourdes Teixeira Amorim¹  Manuela Da Silva¹  Marcia Dos Santos Lazéra¹ 

关键词: Candida;    fluconazole;    antifungal susceptibility;    disk diffusion method;   

DOI  :  10.1590/S1517-838246220120023

来源: SciELO

【 摘 要 】

One hundred and forty-one Candida species isolated from clinical specimens of hospitalized patients in Rio de Janeiro, Brazil, during 2002 to 2007, were analized in order to evaluate the distribution and susceptibility of these species to fluconazole. Candida albicans was the most frequent species (45.4%), followed by C. parapsilosis sensu lato (28.4%), C. tropicalis (14.2%), C. guilliermondii (6.4%), C. famata (2.8%), C. glabrata (1.4%), C. krusei (0.7%) and C. lambica (0.7%). The sources of fungal isolates were blood (47.5%), respiratory tract (17.7%), urinary tract (16.3%), skin and mucous membrane (7.1%), catheter (5.6%), feces (2.1%) and mitral valve tissue (0.7%). The susceptibility test was performed using the methodology of disk-diffusion in agar as recommended in the M44-A2 Document of the Clinical and Laboratory Standards Institute (CLSI). The majority of the clinical isolates (97.2%) was susceptible (S) to fluconazole, although three isolates (2.1%) were susceptible-dose dependent (S-DD) and one of them (0.7%) was resistant (R). The S-DD isolates were C. albicans, C. parapsilosis sensu lato and C. tropicalis. One isolate of C. krusei was resistant to fluconazole. This work documents the high susceptibility to fluconazole by Candida species isolated in Rio de Janeiro, Brazil.

【 授权许可】

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