Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile

Revista de microbiologia

Melhem, Marcia de Souza Carvalho¹  Szeszs, Maria Walderez²  Ribeiro, Marcos Dornelas³  Amorim, Efigênia de Lourdes Teixeira⁴  Neufeld, Paulo Murillo⁵ 

[1] Fundação Oswaldo Cruz, Rio de Janeiro, Brasil;Instituto Adolfo Lutz, São Paulo, Brasil;Instituto Estadual de Hematologia Arthur da Siqueira Cavalcante, Rio de Janeiro, Brasil;Laboratório Sérgio Franco, Rio de Janeiro, Brasil;Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

关键词: Candida;    fluconazole;    antifungal susceptibility;    disk diffusion method.;   

DOI  :  10.1590/S1517-838246220120023

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Microbiologia / Brazilian Society for Microbiology

【 摘 要 】

One hundred and forty-one Candida species isolated from clinical specimens of hospitalized patients in Rio de Janeiro, Brazil, during 2002 to 2007, were analized in order to evaluate the distribution and susceptibility of these species to fluconazole. Candida albicans was the most frequent species (45.4%), followed by C. parapsilosis sensu lato (28.4%), C. tropicalis (14.2%), C. guilliermondii (6.4%), C. famata (2.8%), C. glabrata (1.4%), C. krusei (0.7%) and C. lambica (0.7%). The sources of fungal isolates were blood (47.5%), respiratory tract (17.7%), urinary tract (16.3%), skin and mucous membrane (7.1%), catheter (5.6%), feces (2.1%) and mitral valve tissue (0.7%). The susceptibility test was performed using the methodology of disk-diffusion in agar as recommended in the M44-A2 Document of the Clinical and Laboratory Standards Institute (CLSI). The majority of the clinical isolates (97.2%) was susceptible (S) to fluconazole, although three isolates (2.1%) were susceptible-dose dependent (S-DD) and one of them (0.7%) was resistant (R). The S-DD isolates were C. albicans, C. parapsilosis sensu lato and C. tropicalis. One isolate of C. krusei was resistant to fluconazole. This work documents the high susceptibility to fluconazole by Candida species isolated in Rio de Janeiro, Brazil.

【 授权许可】

CC BY-NC