Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction

Brazilian Journal of Microbiology

Marcus Mandolesi Sá²  Misael Ferreira²  Emerson Silva Lima¹  Ivanildes Dos Santos¹  Patrícia Puccinelli Orlandi¹  Luciano Fernandes¹ 

[1],Universidade Federal de Santa Catarina Departamento de Química Florianópolis SC ,Brazil

关键词: antimicrobial;    allylic thiocyanate;    Morita-Baylis-Hillman reaction;    MRSA;   

DOI  :  10.1590/S1517-83822014000300007

来源: SciELO

【 摘 要 】

Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.

【 授权许可】

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