Effect of alcohols on filamentation, growth, viability and biofilm development in Candida albicans

Brazilian Journal of Microbiology

Nitin M Chauhan¹  Ravikumar B Shinde¹  S. Mohan Karuppayil¹ 

[1] ,FIST DST

关键词: alcohols;    signalling;    morphogenesis;    biofilms;    yeast metabolism;    Candida albicans;   

DOI  :  10.1590/S1517-83822014005000012

来源: SciELO

【 摘 要 】

In this study we report the potential of alcohols as morphogenetic regulators in Candida albicans. All the alcohols tested influenced various modes of growth like planktonic as well as biofilm forms. Viability was affected at high concentrations. Among the alcohols, the response of C. albicans to amyl alcohol (pentanol) was noteworthy. Amyl alcohol at a concentration 0.5% which was not inhibitory to growth and viability specifically inhibited morphogenetic switching from yeast to hyphal forms. It also inhibited normal biofilm development favoring yeast dominated biofilms. Based on this study we hypothesize that alcohols produced under anaerobic conditions may not favor biofilm development and support dissemination of yeast cells. Since anaerobic conditions are not found to favor production of quorum sensing molecules like farnesol, the alcohols may play a role in morphogenetic regulation.

【 授权许可】

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