Efficacy evaluation of some antibiotics against syrian brucella spp isolates, in vitro

Brazilian Journal of Microbiology

Mazen Safi¹  Ayman Al-mariri¹ 

[1] ,Atomic Energy Commission Department of Molecular Biology and Biotechnology Damascus,Syria

关键词: Antibiotics;    Brucella;    quinolones;   

DOI  :  10.1590/S1517-83822012000400005

来源: SciELO

【 摘 要 】

Brucellosis is an endemic zoonosis in Syria, affecting large numbers of animals and there are an increasing number of cases in humans. The aim of this study is to investigate the in vitro efficacy of various traditional and new antibiotics against89 Brucella isolates (isolated from domestic animals) collected from different Syrian regions. Minimum inhibitory concentrations (MICs) of seventeen antibiotics were determined. Ciprofloxacin and ofloxacin were the most effective antibiotics, whereas sparfloxacin, levofloxacin, doxycycline and tetracycline had a moderate activity. In contrast, moxifloxacin and rifampicin had a low activity, while streptomycin, spiramycin and cephalosporines were ineffective. As a result, we come to the conclusion that a combination between one effective quinolone and doxycycline has a good efficacy against Brucella. Further in vivo studies are necessary to support this suggestion.

【 授权许可】

CC BY-NC   
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