Antiviral activity of Agaricus blazei Murrill ss. Heinem extract against human and bovine herpesviruses in cell culture

Brazilian Journal of Microbiology

Rafaela Bruggemann²  Janaina Matsuo Orlandi²  Fabricio Jose Benati²  Ligia Carla Faccin²  Mario Sergio Mantovani¹  Carlos Nozawa²  Rosa Elisa Carvalho Linhares² 

[1] ,Universidade Estadual de Londrina Departamento de Microbiologia Londrina PR ,Brasil

关键词: Agaricus blazei;    BoHV-1;    HSV-1;    antiviral activity;    Agaricus blazei;    BoHV-1;    HSV-1;    atividade antiviral;   

DOI  :  10.1590/S1517-83822006000400029

来源: SciELO

【 摘 要 】

The aqueous extract of Agaricus blazei Murill ss. Heinem, a basidiomycete native from Brazil, frequently used by popular medicine, mainly in the form of tea, was assessed to its antiviral action against herpes simplex type 1 (HSV-1) and bovine herpes type 1 (BoHV-1) in HEp-2 cell culture. Viral replication inhibition was evaluated by plaque assay and immunofluorescence test. The extract demonstrated virucide action for both viruses, being more effective against HSV-1, inhibiting its infectivity in 78.4 and 73.9% at the concentrations of 50 and 100 µg/mL, respectively moreover, reduction in 47% the number of fluorescent cells was observed for both concentrations. The extract also showed discrete therapeutic activity. These results suggest that A. blazei extract acts mainly in the viral particle, however, the effect during virus replication can not be ruled out.

【 授权许可】

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