Influence of subinhibitory concentrations of antimicrobials on hydrophobicity, adherence and ultra-structure of Fusobacterium nucleatum

Brazilian Journal of Microbiology

Ana C. Okamoto²  Elerson Gaetti-jardim Jr.²  Victor E. Arana-chavez¹  Mario J. Avila-campos² 

[1] ,Universidade de São Paulo Instituto de Ciências Biomédicas Departmento de MicrobiologiaSão Paulo SP ,Brasil

关键词: Fusobacterium nucleatum;    hydrophobicity;    adherence;    antimicrobial;    ultra-structure;    Fusobacterium nucleatum;    hidrofobicidade;    aderência;    antimicrobianos;    ultra-estrutura;   

DOI  :  10.1590/S1517-83822002000200017

来源: SciELO

【 摘 要 】

Fusobacterium nucleatum is considered a bridge organism between earlier and later colonizers in dental biofilms and a putative periodontopathogen. In Dentistry, antimicrobial agents are used for treatment and control of infectious diseases associated with dental plaque. Antiseptics have been used in association with antibiotics to reduce infections after oral surgeries. In this study, the influence of subinhibitory concentrations (SC) of chlorhexidine, triclosan, penicillin G and metronidazole, on hydrophobicity, adherence to oral epithelial cells, and ultra-structure of F. nucleatum was examined. All isolates were susceptible to chlorhexidine, triclosan, and metronidazole; however, most of the isolates were susceptible to penicillin G, and all of them were hydrophilic when grown with or without antimicrobials. Adherence was decreased by all antimicrobials. Results suggest that adherence of F. nucleatum was influenced by adhesins because structures such as fimbries or capsule were not observed by transmission electronic microscope.

【 授权许可】

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