Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds

Brazilian Archives of Biology and Technology

Eduardo Sarmento Valente²  Ethel Mizrahy Cuperschmid¹  Tarcisio Passos Ribeiro De Campos¹ 

[1] ,Centro de Desenvolvimento da Tecnologia NuclearBelo Horizonte MG ,Brasil

关键词: Brachytherapy;    ceramic seeds;    holmium;    cancer control;    HeLa cells;   

DOI  :  10.1590/S1516-89132011000500013

来源: SciELO

【 摘 要 】

This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy.

【 授权许可】

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