Effect of mannitol on the pharmacokinetics of amikacin in wistar rats

Brazilian Archives of Biology and Technology

Hugo Juárez Olguín¹  Miriam Carrasco Portugal¹  Janett Flores Pérez¹  Angélica Camacho Vieyra¹  Carmen Flores Pérez¹  Alfonso Alfaro Rodríguez² 

[1] ,National Institute of Pediatrics Laboratory of Pharmacology México

关键词: Pharmacokinetics;    interactions;    amikacin;    mannitol;    antibiotics;    diuretics;   

DOI  :  10.1590/S1516-89132009000400006

来源: SciELO

【 摘 要 】

The study analyzed the effect of mannitol on the pharmacokinetics (PK) of amikacin. Adult Wistar rats were treated as follows: Group 1 (G1) received mannitol for three days, Group 2 (G2) received mannitol plus 10 mg/kg of amikacin simultaneously, and Group 3 only amikacin. The PK study was conducted on the 4th day. For which, blood samples were drawn at fixed times during 24 h and immunoenzymatically analyzed. Results revealed significant differences (p<0.05) between the groups, e.g. Cmax were 62.26 ± 15.75 µg/ml for G1, 72.63 ± 24.80 µg/ml for G2 and 68.61 ± 27.40 µg/ml for G3. The AUC also differed in the three groups, being largest for G2, 222.52 ± 47.30 µg/ml/h, and smallest for G1, 135.59 ± 39.00 µg/ml/h. Alteration of the PK parameters observed between the groups must be considered when both drugs are prescribed, although human studies are necessary to confirm the results.

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