Induction of an antigen specific gut inflammatory reaction in mice and rats: a model for human Inflammatory Bowel Disease

Brazilian Archives of Biology and Technology

Gerlinde Agate Platais Brasil Teixeira²  Danielle Mota Fontes Antunes²  Archimedes Barbosa De Castro Júnior²  Janilda Pacheco Da Costa²  Patrícia Olaya Paschoal²  Sylvia Maria Nicolau Campos²  Monique De Morais Bitetti Pedruzzi²  Vinicius Da Silva Araújo²  Luis Antônio Botelho Andrade¹  Silvana Ramos Farias Moreno¹  Alberto Felix Antonio Da Nobrega¹  Gilberto Perez Cardoso¹ 

[1] ,Universidade Federal Fluminense Instituto de Biologia Laboratório do Grupo de Imunologia GastrintestinalNiterói RJ ,Brasil

关键词: Food allergy;    peanuts;    inflammatory bowel disease;    rats;    mice;   

DOI  :  10.1590/S1516-89132009000300012

来源: SciELO

【 摘 要 】

Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time dependent alterations of the gut similar to celiac disease. In conclusion, results suggested that this experimental model was a convenient tool to study the evolution of alterations in chronic antigen specific gut inflammatory process.

【 授权许可】

CC BY-NC   
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