Effect of medicinal plants on the parasitemia of Trypanosoma cruzi and on the biodistribution of sodium pertechnetate (Na99mTcO4)

Brazilian Archives of Biology and Technology

Roseane Pereira Da Silva²  Cecília Maria De Carvalho Xavier Holanda¹  Vanessa Santos De Arruda Barbosa²  Daniel Pereira De Oliveira¹  Natália Alves Lima¹  Antônia Cláudia Jácome Da Câmara¹  Aldo Da Cunha Medeiros²  Maria Helena Spyrides Constantino¹ 

[1] ,Universidade Federal do Rio Grande do Norte Centro de Ciências da Saúde Natal RN ,Brasil

关键词: Aloe vera;    Artemisia vulgaris;    technetium-99m;    Trypanosoma cruzi;    parasitemia;    biodistribution;    Aloe vera;    Artemisia vulgaris;    tecnécio-99m;    Trypanosoma cruzi;    parasitemia;    biodistribuição;   

DOI  :  10.1590/S1516-89132008000700034

来源: SciELO

【 摘 要 】

Artemisia vulgaris (AV) is an antihelmintic and antimalarial drug; Aloe vera(babosa) acts as antidiabetic, laxative and anti-inflammatory;Benznidazole (BZ) is a trypanocidal of Trypanosoma cruzi (TC). Technetium-99m (99mTc) has been used in nuclear medicine to obtain diagnostic images. This study evaluated the plant effects in TC parasitemia and on the biodistribution of 99mTc in mice. Twenty mice were infected by TC. At the peak of parasitemia, 5 mice received babosa; 5 received AV and 5 received BZ. The parasitemia was determined at 0, 2, 4 and 6 h of drugs administration. Five infected mice without drugs, 5 mice without TC and the group treated with AV, received 99mTc. The radioactivity was calculated. Infected mice that received babosa reduced significantly (p<0.05) the TC parasitemia. The percentage of activity per gram (%ATI/g) decreased significantly on the AV group. These results indicate that babosa possibly is an anti-TC drug and AV reduces the %ATI/g probably due to its biological effects.

【 授权许可】

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