Effect of paclitaxel (Taxol®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in female Wistar rats

Brazilian Archives of Biology and Technology

Cecília Maria De Carvalho Xavier Holanda²  Elias Herculano De Oliveira²  Louisianny Guerra Da Rocha²  Vanessa Santos De Arruda Barbosa¹  Maria Helena Constantino Spyrides¹  Cícero Flávio Soares Aragão¹  Aldo Da Cunha Medeiros¹ 

[1] ,Universidade Federal do Rio Grande do Norte Centro de Biociências Departamento de Microbiologia e ParasitologiaNatal RN ,Brasil

关键词: paclitaxel;    drug interaction;    radiopharmaceuticals;    Na99mTcO4;    antitumoral drug;    cancer;   

DOI  :  10.1590/S1516-89132008000700031

来源: SciELO

【 摘 要 】

The evidence that natural or synthetic drugs can affect the biodistribution of radiopharmaceuticals (radiobiocomplexes) in setting of nuclear medicine clinic is already known. We studied the effect of Paclitaxel, an anti-neoplastic agent for the treatment of solid tumors, on the biodistribution of Na99mTcO4 in female rats. Paclitaxel (1mg/mL/week) was administered into animals in single dose during 3 weeks, with interval of 1 week among them. The control group received NaCl 0.9% solutions by the same via. One hour after the last dose, it was injected Na99mTcO4 in the animals. The percentage of activity per gram (%ATI/g) and biochemical and hematological determinations were performed. A significant increase were found in alanine aminotransferase, aspartate aminotransferase, glucose and in the %ATI/g of some organs (ovaries, uterus, vagina, breasts, large intestine and liver).These results can be associated, probably, to the capacity of paclitaxel to alter the biodistribution of Na99mTcO4 and the metabolism of glucose and hepatic enzymes.

【 授权许可】

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