Rats offspring exposed to Ipomoea Carnea and handling during gestation: neurochemical evaluation

Brazilian Archives of Biology and Technology

Aline Schwarz¹  Rosana Zoriki Hosomi²  Jorge Camilo Flório²  Maria Martha Bernardi²  Silvana Lima Górniak²  Helenice Souza Spinosa² 

[1] ,Universidade Federal do Rio Grande do Norte Departamento de Análises Clínicas e ToxicológicasRN ,Brasil

关键词: Ipomoea carnea;    Neurotransmitter;    Perinate;    Rats;    Stress;   

DOI  :  10.1590/S1516-89132007000300009

来源: SciELO

【 摘 要 】

The present study evaluated the central monoamine levels of male and female adult rat offspring exposed orally by gavage to 0.0, 0.7, 3.0 and 15.0 mg/kg I. carnea aqueous extract daily, from gestation day (GD) 5 to GD 21. Several alterations in the monoamine activity systems were observed. However, the major differences were noted between the 0.0 mg/kg and the no gavage control groups, showing that alterations showing that alterations were not due to the alterations to the aqueous extract. The control data showed that gavage and handling of dams were stressful enough to produce a significant decline in 3,4-dihydroxyphenylacetic acid (DOPAC) and an increase in vanilmandelic acid (VMA), indicating decreased dopamine (DA) and enhanced norepinephrine (NE) activity, respectively.

【 授权许可】

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