Ordered mesoporous silica carrier system applied in nanobiothecnology

Brazilian Archives of Biology and Technology

Andreza De Sousa¹  Edésia Martins Barros De Sousa¹ 

[1] ,Centro de Desenvolvimento da Tecnologia NuclearBelo Horizonte MG ,Brasil

关键词: Mesoporous materials;    drug delivery system;    cancer treatment;    SBA15;   

DOI  :  10.1590/S1516-89132005000700036

来源: SciELO

【 摘 要 】

Ordered mesoporous materials like SBA15 possess a network of channels and pores of well-defined size in the nanoscale range (2-50 nm). This particular pore architecture makes them suitable candidates for hosting and delivery under appropriate conditions of a variety of molecules of pharmaceutical interest, including radiopharmaceuticals. The characteristics of SBA-15 prepared in different temperatures and the behavior of this system regarding microencapsulation of a model drug were investigated. The calcined samples were formed in 0.2 g disks and were soaked in a solution of atenolol used as a model drug. The modification of the aging temperature provoked changes in the structure of the pores, indicating the presence of microporosity and connections between mesopores. Aging the materials at a higher temperature resulted in no microporosity and this fact influenced the control of the release of the model drug.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License