A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment

Materials

Adillys Marcelo da Cunha Santos¹  Bianca Viana de Sousa²  Rayssa de Sousa Victor³  Lisiane Navarro de Lima Santana⁴  Romualdo Rodrigues Menezes⁴  Gelmires de Araújo Neves⁴ 

[1] Center for Science and Technology in Energy and Sustainability (CETENS), Federal University of Recôncavo da Bahia (UFRB), Feira de Santana 44042-280, Brazil;Department of Chemical Engineering, Federal University of Campina Grande, Campina Grande 58429-900, Brazil;Graduate Program in Materials Science and Engineering, Laboratory of Materials Technology (LTM), Federal University of Campina Grande, Campina Grande 58429-900, Brazil;Laboratory of Materials Technology (LTM), Department of Materials Engineering, Federal University of Campina Grande, Campina Grande 58429-900, Brazil;

关键词: chitosan;    biopolymer;    tissue engineering;    drug delivery system;    cancer treatment;   

DOI  :  10.3390/ma13214995

来源: DOAJ

【 摘 要 】

Chitosan, derived from chitin, is a biopolymer consisting of arbitrarily distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine that exhibits outstanding properties— biocompatibility, biodegradability, non-toxicity, antibacterial activity, the capacity to form films, and chelating of metal ions. Most of these peculiar properties are attributed to the presence of free protonable amino groups along the chitosan backbone, which also gives it solubility in acidic conditions. Moreover, this biopolymer can also be physically modified, thereby presenting a variety of forms to be developed. Consequently, this polysaccharide is used in various fields, such as tissue engineering, drug delivery systems, and cancer treatment. In this sense, this review aims to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications. We present the most relevant and new information about this polysaccharide-based biomaterial’s applications in distinct fields and also the ability of chitosan and its various derivatives to selectively permeate through the cancer cell membranes and exhibit anticancer activity, and the possibility of adding several therapeutic metal ions as a strategy to improve the therapeutic potential of this polymer.

【 授权许可】

Unknown