Evaluation of gastric anti-ulcer activity in a hydro-ethanolic extract from Kielmeyera coriacea

Brazilian Archives of Biology and Technology

Yara Cavalcante Fortes Goulart¹  Vania Ramos Sela¹  Simoni Obici¹  Juliana Vanessa Colombo Martins¹  Fernanda Otobone¹  Diogenes Aparicio Cortez¹  Elisabeth Aparecida Audi¹ 

[1] ,Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia Maringá PR ,Brazil

关键词: Acute stress;    anti-ulcer activity;    ethanol-acid;    Indomethacin;    Kielmeyera coriacea Mart. (Guttiferae);   

DOI  :  10.1590/S1516-89132005000200007

来源: SciELO

【 摘 要 】

The antiulcer activity of a hydro-ethanolic extract prepared from the stems of Kielmeyera coriacea Mart. (Guttiferae) was evaluated in rats employing the ethanol-acid, acute stress and Indomethacin models to induce experimental gastric ulcers. Treatment with K coriacea hydro-ethanolic extract provided significant antiulcer protection in the ethanol-acid and Indomethacin models, but not in the acute stress model. These results suggested that the K coriacea hydro-ethanolic extract increased resistance to necrotizing agents, providing a direct, protective effect on the gastric mucosa.

【 授权许可】

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