Influence of tetracycline in the hepatic and renal development of rat's offspring

Brazilian Archives of Biology and Technology

Ana Lourdes Da Silva Machado¹  Adriana Aigotti Haberbeck Brandão¹  Cláudia Maria De Oliveira Monteiro Da Silva¹  Rosilene Fernandes Da Rocha¹ 

[1] ,Universidade Estadual Paulista Departament of Biosciencie ; Buccal Diagnostic São José dos Campos SP ,Brasil

关键词: Pregnancy;    Development;    Tetracycline;    Hepatotoxicity;    Nephrotoxicity;   

DOI  :  10.1590/S1516-89132003000100008

来源: SciELO

【 摘 要 】

This study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.

【 授权许可】

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