Radiolabelled cytokines for imaging chronic inflammation

Brazilian Archives of Biology and Technology

Alberto Signore¹  Calogero D'alessandria¹  Alessio Annovazzi¹  Francesco Scopinaro¹ 

[1] ,University 'La Sapienza' 2nd Faculty of Medicine Nuclear MedicineRoma,Italy

关键词: Radiolabelled cytokines;    chronic inflammation;    imaging;   

DOI  :  10.1590/S1516-89132002000500004

来源: SciELO

【 摘 要 】

Diagnosis and particularly follow-up of chronic inflammatory disorders could be often difficult in clinical practice. Indeed, traditional radiological techniques reveal only structural tissue alterations and are not able to monitor functional changes occurring in tissues affected by chronic inflammation. The continuous advances in the knowledge of the pathophysioloy of chronic disorders, combined with the progress of radiochemistry, led to the development of new specific radiolabelled agents for the imaging of chronic diseases. In this scenario, cytokines, due to their pivotal role in such diseases, represent good candidates as radiopharmaceuticals.

【 授权许可】

CC BY-NC   
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