Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton

Brazilian Archives of Biology and Technology

Kelly Fabiane Santos Ricardo²  Tânia Toledo De Oliveira²  Tanus Jorge Nagem¹  Aloisio Da Silva Pinto¹  Maria Goreti Almeida Oliveira²  José Francisco Soares¹ 

[1] ,Universidade Federal de Viçosa Departamento de Bioquímica e Biologia Molecular Viçosa MG ,Brazi

关键词: Morin;    Quercetin;    Nicotinic Acid;    Lipid;    Cholesterol;    Cholesterol-HDL;    Triacylglycerols;    Rats;    Hyperlipidemic;   

DOI  :  10.1590/S1516-89132001000300007

来源: SciELO

【 摘 要 】

Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morin-nicotinic acid combination showed the best triacylglycerols results. Results showed that flavonoids could be beneficious in the treatment of coronary diseases.

【 授权许可】

CC BY-NC   
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