Assessment of the plan for pre-exposition vaccination with Fuenzalida-Palacios anti-rabies vaccine

Brazilian Archives of Biology and Technology

Angela Aparecida Preto²  Elisa Maines Gomes²  Maurício José Fernandes²  Nei Adolfo Hennig²  Pedro Manoel Leal Germano¹ 

[1] ,Instituto de Tecnologia do ParanáCuritiba PR ,Brazil

关键词: Immunization;    rabies vaccine;    antibodies;    neutralization;    Fuenzalida-Palacios;   

DOI  :  10.1590/S1516-89132000000300002

来源: SciELO

【 摘 要 】

Studies ere carried out to monitor the titres of anti-rabies antibodies taken from individuals exposed to the risk of infection. Fifty-seven individuals aged between 20 and 40, were vaccinated with a minimum titre of 1.3 IU Fuenzalida-Palacios type anti-rabies vaccine. The vaccination plan consisted of the application of three doses at two day intervals and a booster applied 28 days after the final dose. The accompainment of the antibody titres was achieved by means of the seroneutralization test over a total period of 18 months. Through the monitoring carried out, it was found to be necessary to apply a booster vaccination to part of the group. Some of these individuals were revaccinated with Fuenzalida-Palacios type vaccine with a minimum titre of 1.3 IU. And some with cellular vaccine with a minimum titre of 2.5 IU. All the individuals responded with titres greater than 0.5 IU, maintaining these levels until the end of the observation period, demonstrating a ready anamnestic response to both immunogens.

【 授权许可】

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