Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene

Revista Brasileira de Hematologia e Hemoterapia

Marcelo Bellesso¹  Rodrigo Santucci¹  Daniela Ferreira Dias¹  Renato Centrone¹  Renata Campos Elias¹ 

关键词: Leukemia;    myeloid;    chronic;    atypical;    BCR-ABL negative;    Myelodysplastic-myeloproliferative diseases;    Proto-oncogene proteins c-bcr;   

DOI  :  10.5581/1516-8484.20130044

来源: SciELO

【 摘 要 】

We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemiawith a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance tothe tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, thepatient showed no hematologic response and was submitted to an allogeneic bonemarrowtransplantation. Fifty-three days after the procedure, he died due to acutegraft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in onlyfive patients in the whole world, with three clinical presentations:myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloidleukemia.

【 授权许可】

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