Revista Brasileira de Hematologia e Hemoterapia | |
Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene | |
Marcelo Bellesso1  Rodrigo Santucci1  Daniela Ferreira Dias1  Renato Centrone1  Renata Campos Elias1  | |
关键词: Leukemia; myeloid; chronic; atypical; BCR-ABL negative; Myelodysplastic-myeloproliferative diseases; Proto-oncogene proteins c-bcr; | |
DOI : 10.5581/1516-8484.20130044 | |
来源: SciELO | |
【 摘 要 】
We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemiawith a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance tothe tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, thepatient showed no hematologic response and was submitted to an allogeneic bonemarrowtransplantation. Fifty-three days after the procedure, he died due to acutegraft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in onlyfive patients in the whole world, with three clinical presentations:myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloidleukemia.
【 授权许可】
CC BY-NC-ND
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