The influence of hydroxyurea on oxidative stress in sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia

Lidiane De Souza Torres²  Danilo Grünig Humberto Da Silva²  Edis Belini Junior²  Eduardo Alves De Almeida²  Clarisse Lopes De Castro Lobo¹  Rodolfo Delfini Cançado¹  Milton Artur Ruiz¹  Claudia Regina Bonini-domingos² 

[1] ,Universidade Estadual PaulistaSão José do Rio Preto SP ,Brazil

关键词: Hemoglobinopathies;    Oxidative stress;    Anemia;    sickle cell;    Hydroxyurea;   

DOI  :  10.5581/1516-8484.20120106

来源: SciELO

【 摘 要 】

OBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy. METHODS: Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capacity and plasma glutathione levels. RESULTS: Thiobarbituric acid reactive species values were higher in patients without specific medication, followed by patients taking hydroxyurea and the Control Group (p < 0.0001). The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione). Thiobarbituric acid reactive species levels were correlated with higher hemoglobin S levels (r = 0.55; p = 0.0040) and lower hemoglobin F concentrations(r = -0.52; p = 0.0067). On the other hand, plasma glutathione levels were negatively correlated with hemoglobin S levels (r = -0.49; p = 0.0111) and positively associated with hemoglobin F values (r = 0.56; p = 0.0031). CONCLUSION: Sickle cell anemia patients have high oxidative stress and, conversely, increased antioxidant activity. The increase in hemoglobin F levels provided by hydroxyurea and its antioxidant action may explain the reduction in lipid peroxidation and increased antioxidant defenses in these individuals.

【 授权许可】

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