Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

Revista Brasileira de Hematologia e Hemoterapia

Darcielle Bruna Dias Elias¹  Lilianne Brito Da Silva Rocha¹  Maritza Barbosa Cavalcante¹  Alano Martins Pedrosa¹  Izabel Cristina Bandeira Justino¹  Romélia Pinheiro Gonçalves¹ 

[1] ,Universidade Federal do CearáFortaleza CE ,Brazil

关键词: Lactate dehydrogenase;    Malonaldehyde;    Anemia;    sickle cell;    Nitrite;   

DOI  :  10.5581/1516-8484.20120069

来源: SciELO

【 摘 要 】

BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. OBJECTIVE: To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle cell disease not under treatment with hydroxyurea in outpatients at a university hospital in Fortaleza, Ceará, Brazil. METHODS: Forty-four patients diagnosed with sickle cell disease were enrolled at baseline. Diagnosis was confirmed by evaluating the beta globin gene using polymerase chain reaction-restriction fragment length polymorphism. The concentration of fetal hemoglobin was obtained by high-performance liquid chromatography. Serum levels of nitrite, malonaldehyde and lactate dehydrogenase were measured by biochemical methods. RESULTS: Significantly higher levels of lactate dehydrogenase, nitrite and malonaldehyde were observed in patients with sickle cell disease compared to a control group. The study of the correlation between fetal hemoglobin levels and these variables showed a negative correlation with nitrite levels. No correlation was found between fetal hemoglobin and malonaldehyde or lactate dehydrogenase. When the study population was stratified according to fetal hemoglobin levels, a decrease in the levels of nitrite was observed with higher levels of fetal hemoglobin (p-value = 0.0415). CONCLUSION: The results show that, similar to fetal hemoglobin levels, the concentration of nitrite can predict the clinical course of the disease, but should not be used alone as a modulator of prognosis in patients with sickle cell disease.

【 授权许可】

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