Revista Brasileira de Psiquiatria | |
New frontiers in the study of memory mechanisms | |
Cristiane R.g. Furini1  Jociane C. Myskiw1  Fernando Benetti1  Ivan Izquierdo1  | |
关键词: Memory; persistence; consolidation; synaptic tagging; extinction; | |
DOI : 10.1590/1516-4446-2012-1046 | |
来源: SciELO | |
【 摘 要 】
We review recent work on three major lines of memory research: a) the possible role of the protein kinase M-zeta (PKMzeta) in memory persistence; b) the processes of “synaptic tagging and capture” in memory formation; c) the modulation of extinction learning, widely used in the psychotherapy of fear memories under the name of “exposure therapy”. PKMzeta is a form of protein kinase C (PKC) that apparently remains stimulated for months after the consolidation of a given memory. Synaptic tagging is a mechanism whereby the weak activation of one synapse can tag it with a protein so other synapses in the same cell can reactivate it by producing other proteins that bind to the tag. Extinction, once mistakenly labeled as a form of forgetting, is by itself a form of learning; through it animals can learn to inhibit a response. We now know it can be modulated by neurotransmitters or by synaptic tagging, which should enable better control of its clinical use.
【 授权许可】
CC BY-NC
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