Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety

Revista Brasileira de Psiquiatria

Juliana Belo Diniz²  Euripedes Constantino Miguel²  Amanda Ribeiro De Oliveira¹  Adriano Edgar Reimer¹  Marcus Lira Brandão¹  Maria Alice De Mathis²  Marcelo Camargo Batistuzzo²  Daniel Lucas Conceição Costa²  Marcelo Queiroz Hoexter² 

[1] ,Universidade de São Paulo Hospital das Clínicas Medical School Department & Institute of PsychiatrySão Paulo,Brazil

关键词: obsessive-compulsive disorder;    anxiety disorders;    fear;    stress disorders;    post-traumatic;    neuroimaging;    epidemiology;    treatment;    transtornos obsessivo-compulsivos;    transtornos da ansiedade;    medo;    transtorno do estresse;    pós-traumático;    neuroimagem;    epidemiologia;    tratamento;   

DOI  :  10.1590/S1516-44462012000500007

来源: SciELO

【 摘 要 】

Anxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions that are not always compatible with those previously associated with other anxiety disorders. OBJECTIVES: The aim of this study is to review the degree of overlap between OCD and other anxiety disorders phenomenology and pathophysiology to support the rationale that guides research in this field. RESULTS: Clues about the neurocircuits involved in the manifestation of anxiety disorders have been obtained through the study of animal anxiety models, and structural and functional neuroimaging in humans. These investigations suggest that in OCD, in addition to dysfunction in cortico-striatal pathways, the functioning of an alternative neurocircuitry, which involves amygdalo-cortical interactions and participates in fear conditioning and extinction processes, may be impaired. CONCLUSION: It is likely that anxiety is a relevant dimension of OCD that impacts on other features of this disorder. Therefore, future studies may benefit from the investigation of the expression of fear and anxiety by OCD patients according to their type of obsessions and compulsions, age of OCD onset, comorbidities, and patterns of treatment response.

【 授权许可】

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