Homozygosity for the APOE E4 allele is solely associated with lower cognitive performance in Brazilian community-dwelling older adults: the Bambuí Study

Revista Brasileira de Psiquiatria

Sandra Regina Quintino-santos²  Maria Fernanda Lima-costa²  Elizabeth Uchoa²  Josélia Oliveira De Araujo Firmo²  Emílio Hideyuki Moriguchi¹  Érico De Castro-costa² 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisa Rene Rachou Laboratório de Epidemiologia e Antropologia Médica

关键词: Cognitive Performance;    Apolipoprotein E;    MMSE;    Elderly;    Desempenho Cognitivo;    Apolipoproteína E;    MEEM;    Idoso;   

DOI  :  10.1016/j.rbp.2012.06.005

来源: SciELO

【 摘 要 】

OBJECTIVE: To investigate if APOE E4 allelic status is associated with the cognitive functioning of elderly individuals. METHODS: Participants (n = 1,408) from the Bambuí Cohort Study of Aging were selected based on the results from both variables (APOE genotype and MMSE score). Gender, age, education, marital status, skin color, GHQ score and biological measures were used as confounding factors for adjusting the logistic regression. RESULTS: The population was in Hardy-Weinberg equilibrium, and the APOE E4 allele frequency was 13.4%. APOE E4 allele homozygosity conferred a superior odds ratio (OR) for cognitive impairment (OR = 3.1) compared to E4 allele heterozygosity (OR = 0.99) even when adjusted for age, sex, education, marital status, skin color, triglycerides, HDL, systolic pressure, and GHQ (OR = 2.9). No differences were observed between the other covariates. CONCLUSIONS: The APOE E4 allele was observed to have a dramatic effect on cognitive impairment, especially in homozygotes, which comprised approximately 2% of the population.

【 授权许可】

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