Evaluation of light/dark cycle in anxiety- and depressive-like behaviors after regular treatment with methylphenidate hydrochloride in rats of different ages

Revista Brasileira de Psiquiatria

Karin M. Gomes²  Renan P. Souza¹  Cecília G. Inácio²  Samira S. Valvassori²  Gislaine Z. Réus²  Márcio R. Martins²  Clarissa M. Comim²  João Quevedo² 

[1] ,Universidade do Extremo Sul CatarinenseCriciúma SC ,Brazil

关键词: Attention;    Behavior;    Anxiety;    Rats;    Wistar;    Methylphenidate;    Atenção;    Comportamento;    Ansiedade;    Ratos Wistar;    Metilfenidato;   

DOI  :  10.1590/S1516-44462010005000018

来源: SciELO

【 摘 要 】

OBJECTIVE: Methylphenidate hydrochloride is the most widely used medication for treatment and management of attention-deficit hyperactivity disorder. However, the chronic effects of methylphenidate hydrochloride on anxiety- and depressive-like rat behaviors remain poorly investigated. In this context, the present study evaluated the effects of treatment with methylphenidate hydrochloride on anxiety- and depressive-like behaviors using young and adult rats during the light and the dark cycle. METHOD: Male Wistar rats (25 or 60 days old) received a once-daily (in either the light or dark cycle) methylphenidate hydrochloride (2mg/kg) or saline intraperitoneal injection for 28 days. We performed elevated plus maze and forced swimming test two hours after the last injection. RESULTS: The light/dark cycle was a significant factor in the anxiety-like behaviors; however, no significant interaction between all three factors (cycle, age and methylphenidate hydrochloride) was found. Nevertheless, we observed a nominally significant interaction between the light/ dark cycle and age in the forced swimming test. CONCLUSION: Our results have shown that age and the light/dark cycle are more significant modulators of anxiety- and depressive-like behaviors than methylphenidate hydrochloride treatment.

【 授权许可】

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