Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

Revista Brasileira de Psiquiatria

Juliana Fernandes Tramontina¹  Denise Yates²  Pedro Vieira Da Silva Magalhães¹  Clarissa Trentini²  Márcia Kauer Sant'anna¹  Gabriel Rodrigo Fries¹  Hugo Bock²  Maria Luiza Saraiva-pereira²  Flávio Kapczinski¹ 

[1] ,Hospital de Clínicas de Porto Alegre INCT Translational Medicine Molecular Psychiatry LaboratoryPorto Alegre RS ,Brazil

关键词: Bipolar disorder;    Cognitive dissonance;    Brain-derived neurotrophic factor;    Patients;    Genetic polymorphism;    Transtorno bipolar;    Dissonância cognitiva;    Fator neurotrófico derivado do encéfalo;    Pacientes;    Polimorfismo genético;   

DOI  :  10.1590/S1516-44462009000200010

来源: SciELO

【 摘 要 】

OBJECTIVE: In the present study, we investigate the association between the val66met polymorphism of the brain-derived neurotrophic factor (BNDF) and the performance on the Wisconsin Card Sorting Test in a sample of Caucasian Brazilian patients with bipolar disorder. METHOD: Sixty-four patients with bipolar disorder were assessed and their performance on the Wisconsin Card Sorting Test was compared with the allele frequency and genotype of the val66met polymorphism of the brain-derived neurotrophic factor. RESULTS: The percentage of non-perseverative errors was significantly higher among patients with the val/val genotype. There was no association between (BNDF) genotype frequency and other Wisconsin Card Sorting Test domains. CONCLUSION: Our results did not replicate previous descriptions of an association between a worse cognitive performance and the presence of the met allele of the val66met brain-derived neurotrophic factor gene polymorphism.

【 授权许可】

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