期刊论文详细信息
Revista Brasileira de Psiquiatria | |
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder | |
Quirino Cordeiro2  Carolina Cappi2  Aline Santos Sampaio2  Selma Aliotti Palácios1  Carlos Alberto De Bragança Pereira1  Roseli Gedanke Shavitt2  Eurípedes Constantino Miguel2  Luiza Guilherme1  Ana Gabriela Hounie2  | |
[1],Universidade de São Paulo Medical School Department and Institute of PsychiatrySão Paulo SP ,Brazil | |
关键词: Case-control studies; Patients; Polymorphism genetic; Immune system diseases; Obsessive-compulsive disorder; Estudos de casos e controles; Pacientes; Polimorfismo genético; Doenças do sistema imune; Transtorno obsessivo-compulsivo; | |
DOI : 10.1590/S1516-44462009000200009 | |
来源: SciELO | |
【 摘 要 】
OBJECTIVE: Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder. METHOD: The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls. RESULTS: There were no differences in genotypic distributions between patients and controls (χ2 = 0.98; 2 d.f.; p = 0.61). DISCUSSION: Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied. CONCLUSION: The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample.【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202005130161913ZK.pdf | 273KB | download |