Clinical applications of immunoglobulin: update

Revista Brasileira de Hematologia e Hemoterapia

Marcia Cristina Zago Novaretti¹  Carla Luana Dinardo¹ 

[1] ,Instituto do Câncer do Estado de São Paulo Blood Transfusion Service São Paulo SP ,Brazil

关键词: Immunoglobulin;    intravenous;    Plasma;    Purpura;    thrombocytopenic;    idiopathic;    Guillain-Barre syndrome;    Immune system diseases;   

DOI  :  10.5581/1516-8484.20110058

来源: SciELO

【 摘 要 】

Human immunoglobulin is the most used blood product in the clinical practice. Immunoglobulin applications have increased quickly since the elucidation of its immunomodulatory and antiinflammatory properties which turned this blood product into a precious tool in the treatment of numerous diseases that present with humoral immune deficiency or that cause immune system dysfunction. Currently, the approved indications for Ig are: primary immunodeficiencies, secondary immunodeficiencies (multiple myeloma or chronic lymphoid leukemia), Kawasaki syndrome, immune thrombocytopenic purpura, Guillain Barré syndrome, graft-versus-host disease following bone marrow transplantation and repeat infections in HIV children. On the other hand, there are numerous "off-label" indications of immunoglobulin, which represent 20-60% of all clinical applications of this drug. It is important to study all these indications and, above all, the scientific evidence for its use, in order to provide patients with a new therapeutic option without burdening the health system. This review results from a wide selection of papers identified in the Pubmed and Lilacs scientific electronic databases. A group of descriptors were used from human immunoglobulin to the names of each disease that immunoglobulin is clinically applied. Our main objective is to list the numerous indications of immunoglobulin, both authorized and "off-label" and to analyze these indications in the light of the most recent scientific evidence.

【 授权许可】

CC BY-NC-ND   
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