Greater expression of the human leukocyte antigen-G (HLA-G) and interleukin-17 (IL-17) in cervical intraepithelial neoplasia: analytical cross-sectional study

Sao Paulo Medical Journal

Lidyane Neves Miranda¹  Fernanda Priscila Santos Reginaldo¹  Daliana Maria Berenice Oliveira Souza¹  Christiane Pienna Soares¹  Tarsia Giabardo Alves Silva¹  Keyla Borges Ferreira Rocha¹  Carlos André Nunes Jatobá¹  Eduardo Antonio Donadi¹  Joanlise Marco Leon Andrade¹  Ana Katherine Silveira Gonçalves¹  Janaína Cristiana Oliveira Crispim¹ 

关键词: HLA-G antigens;    Interleukin-17;    Cervix uteri;    Immunohistochemistry;    Cervical intraepithelial neoplasia;    Antígenos HLA-G;    Interleucina-17;    Colo do útero;    Imunoistoquímica;    Neoplasia intraepitelial cervical;   

DOI  :  10.1590/1516-3180.2013.7170009

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE:Impaired local cell immunity seems to contribute towards the pathogenesis and progression of cervical intraepithelial neoplasia (CIN), but the underlying molecular mechanisms promoting its progression remain unclear. Identification of new molecular markers for prognosis and diagnosis of early-stage CIN may aid in decreasing the numbers of CIN cases. Several novel immunoregulatory molecules have been discovered over the past few years, including the human leukocyte antigen G (HLA-G), which through interaction with its receptors exerts important tolerogenic functions. Several lines of evidence suggest that T-helper interleukin-17 (IL-17)-producing cells (Th17 cells) may play a role in antitumor immunity. However, recent reports have implicated Th17 cells and their cytokines in both pro and anti-tumorigenic processes. The aim of the study was to evaluate the roles of HLA-G and Th17 in the immunopathogenesis of CIN I.DESIGN AND SETTING:Analytical cross-sectional study with a control group using 58 cervical specimens from the files of a public university hospital providing tertiary-level care.METHODS:We examined HLA-G and IL-17 expression in the cervical microenvironment by means of immunohistochemistry, and correlated these findings with clinical and pathological features.RESULTS:There was a greater tendency towards HLA-G and IL-17 expression in specimens that showed CIN I, thus suggesting that these molecules have a contribution towards cervical progression.CONCLUSION:These findings suggest that HLA-G and IL-17 expression may be an early marker for assessing the progression of cervical lesions.

【 授权许可】

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