Systemic lupus erythematosus activity and beta two microglobulin levels

Sao Paulo Medical Journal

Thelma Larocca Skare¹  Kellen Ferri¹  Marcela Aimone Santos¹ 

关键词: Lupus erythematosus;    systemic;    beta 2-microglobulin;    Inflammation;    Blood sedimentation;    Acute-phase reaction;    Lúpus eritematoso sistêmico;    Microglobulina-2 beta;    Inflamação;    Sedimentação sanguínea;    Reação de fase aguda;   

DOI  :  10.1590/1516-3180.2014.1324703

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease with a cyclical clinical course. Evaluation of the clinical activity of this disease is important for choosing the correct treatment. The objective of this study was to analyze the value of beta-2 microglobulin (β2M) serum levels in determining SLE clinical activity.DESIGN AND SETTING: Cross-sectional analytical study conducted at the rheumatology outpatient clinic of a private university hospital.METHODS: 129 SLE patients were studied regarding disease activity using SLEDAI (SLE Disease Activity Index) and cumulative damage using SLICC ACR (SLE International Collaborating Clinics/American College of Rheumatology Damage Index for SLE). At the same time, the β2M serum level, ESR (erythrocyte sedimentation rate), anti-dsDNA (anti-double-stranded DNA) and C3 and C4 complement fractions were determined.RESULTS: β2M levels correlated positively with SLEDAI (P = 0.02) and ESR (P = 0.0009) and negatively with C3 (P = 0.007). Patients who were positive for anti-dsDNA had higher β2M serum levels (P = 0.009).CONCLUSION: β2M levels are elevated in SLE patients with active disease.

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