Systemic lupus erythematosus and Raynaud's phenomenon

Anais Brasileiros de Dermatologia

Flavia Emilie Heimovski¹  Juliana A. Simioni¹  Thelma Larocca Skare¹ 

关键词: Autoantibodies;    Lupus erythematosus;    systemic;    Prognosis;    Raynaud disease;   

DOI  :  10.1590/abd1806-4841.20153881

来源: SciELO

【 摘 要 】

Abstract:BACKGROUND: Patients with systemic lupus erythematosus seem to belong to different serological and clinical subgroups of the disease. Genetic background can cause the appearance of these subgroups.OBJECTIVE: To determine whether Brazilian patients who have systemic lupus erythematosus and Raynaud's phenomenon differ from those who do not.METHODS: Retrospective analysis of 373 medical records of systemic lupus erythematosus patients studied for demographic, clinical and serological data. A comparative analysis was performed of individuals with and without RP.RESULTS: There was a positive association between Raynaud's phenomenon and age at diagnosis (p=0.02), presence of anti-Sm (p=0.01) antibodies and anti-RNP (p<0.0001). Furthermore, a negative association was found between Raynaud's phenomenon and hemolysis (p=0.01), serositis (p=0.01), glomerulonephritis (p=0.0004) and IgM aCL (p=0.004) antibodies.CONCLUSION: Raynaud's phenomenon patients appear to belong to a systemic lupus erythematosus subset with a spectrum of clinical manifestations located in a more benign pole of the disease.

【 授权许可】

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