Statins for progression of aortic valve stenosis and the best evidence for making decisions in health care

Sao Paulo Medical Journal

Luciana Thiago²  Selma Rumiko Tsuj²  Álvaro Nagib Atallah¹  Maria Eduarda Dos Santos Puga¹  Aécio Flávio Teixeira De Góis¹ 

[1] ,Faculdade de Medicina de Marília

关键词: Aortic valve stenosis;    Hydroxymethylglutaryl-CoA reductase inhibitors;    Atherosclerosis;    Disease progression;    Review [publication type];    Estenose da valva aórtica;    Inibidores de hidroximetilglutaril-CoA redutases;    Aterosclerose;    Avanço da doença;    Revisão;   

DOI  :  10.1590/S1516-31802011000100008

来源: SciELO

【 摘 要 】

In the Western world, calcified aortic valve stenosis is the most common form of valvular heart disease, affecting up to 3% of adults over the age of 75 years. It is a gradually progressive disease, characterized by a long asymptomatic phase that may last for several decades, followed by a short symptomatic phase associated with severe restriction of the valve orifice. Investigations on treatments for aortic valve stenosis are still in progress. Thus, it is believed that calcification of aortic valve stenosis is similar to the process of atherosclerosis that occurs in coronary artery disease. Recent studies have suggested that cholesterol lowering through the use of statins may have a salutary effect on the progression of aortic valve stenosis

【 授权许可】

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