Prevalence and risk factors for cervical intraepithelial neoplasia in HIV-infected women in Salvador, Bahia, Brazil

Sao Paulo Medical Journal

Paula Matos Oliveira²  Rone Peterson Cerqueira Oliveira¹  Iane Érica Martins Travessa¹  Marques Vinícius De Castro Gomes¹  Maria Lícia De Jesus Dos Santos¹  Maria Fernanda Rios Grassi¹ 

[1] ,Escola Bahiana de Medicina e Saúde PúblicaSalvador Bahia ,Brazil

关键词: HIV;    Cervical intraepithelial neoplasia;    Prevalence;    Risk factors;    Brazil;    HIV;    Neoplasia intra-epitelial cervical;    Prevalência;    Fatores de risco;    Brasil;   

DOI  :  10.1590/S1516-31802010000400004

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: The human immunodeficiency virus (HIV) is frequently associated with high-grade intraepithelial neoplasia. Immunosuppression and high HIV viral load are the main risk factors for cervical intraepithelial neoplasia (CIN). The aim of this study was to determine the prevalence of CIN in HIV-infected women in Salvador, Bahia, Brazil, and to describe the risk factors in comparison with non-infected women. DESIGN AND SETTING: Cross-sectional study at the AIDS Reference Center of Bahia and the Gynecological Outpatient Clinic of Fundação Bahiana para o Desenvolvimento da Ciência, in Salvador, Bahia, Brazil. METHODS: Sixty-four HIV-infected women and 76 uninfected women from Salvador were enrolled between May 2006 and May 2007. Associations between CIN and presence of HIV infection, HIV viral load, proportion of T CD4+ lymphocytes and risk factors were evaluated. The independence of the risk factors was investigated using logistic regression. RESULTS: CIN was more prevalent among HIV-infected women than in the control group (26.6% versus 6.6%; P = 0.01). The odds ratio for CIN among HIV-infected women was 3.7 (95% confidence interval, CI: 1.23-11; P = 0.01), after adjusting for the following variables: age at first sexual intercourse, number of partners, number of deliveries and previous history of sexually transmitted disease. CONCLUSION: The prevalence of CIN among HIV-infected women was significantly higher than among women without HIV infection. HIV infection was the most important risk factor associated with the development of cervical lesions.

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