Maternal outcome in HELLP syndrome requiring intensive care management in a Turkish hospital

Sao Paulo Medical Journal

Mehmet Armagan Osmanagaoglu²  Selen Osmanagaoglu¹  Hülya Ulusoy¹  Hasan Bozkaya² 

[1] ,Karadeniz Technical University School of Medicine Department of Obstetrics and GynecologyTrabzon,Turkey

关键词: Maternal mortality;    Pre-eclampsia;    HELLP syndrome;    Intensive care;    High-risk pregnancy;    Mortalidade materna;    Pré-eclâmpsia;    Síndrome HELLP;    Cuidados intensivos;    Gravidez de alto risco;   

DOI  :  10.1590/S1516-31802006000200007

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Despite the development of tertiary care facilities, intensive care and advanced blood banking techniques, pregnancy-related hypertensive disorders are the main cause of maternal mortality in most countries. Our purpose was to determine maternal outcome in pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes and low platelet count) that required intensive care management. DESIGN AND SETTING: Retrospective study at Department of Obstetrics and Gynecology, and Department of Anesthesiology and Reanimation, Karadeniz Technical University, Trabzon, Turkey. METHODS: 37 patients with HELLP syndrome admitted to the obstetric intensive care unit were analyzed retrospectively from 1992 to 2004. RESULTS: All patients were hypertensive, with mean Glasgow coma score (GCS) of 11 ± 3.96. Mean gestational age at delivery was 32 ± 4.09 weeks. Delivery was vaginally in nine and by cesarean section in 27 patients. General anesthesia was used in 12 and spinal anesthesia in 25 patients. Maternal morbidity included acute renal failure (11%), disseminated intravascular coagulation (5%), acute lung edema (3%), severe ascites (11%), pleural effusion (3%), adult respiratory distress syndrome (11%), abruptio placenta (11%), cerebral edema (8%) and cerebral hemorrhage (40%). All patients required transfusions using blood products. There were 11 maternal deaths (30%). CONCLUSION: Because of high maternal mortality and morbidity found among patients with HELLP syndrome, standard antenatal follow-up protocols should be applied, so as to obtain early diagnosis and improve the speed of transfer to obstetric departments with expertise in this field.

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