a-Interferon therapy for HBV-related glomerulonephritis

Sao Paulo Medical Journal

Edmundo Pessoa De Almeida Lopes Neto¹  Lucila Valente Lopes¹  Gianna Mastroianni Kirsztajn¹  Cibele Nascimento Cruz¹  Maria Lucia Gomes Ferraz¹  Antonio Eduardo Benedito Silva¹ 

关键词: Hepatitis B virus;    Membranous glomerulonephritis;    Interferon;   

DOI  :  10.1590/S1516-31801998000500008

来源: SciELO

【 摘 要 】

We report a case of a patient with hepatitis B virus (HBV)-related membranous glomerulonephritis (MGN) who showed improvement after interferon-a (IFN-a) therapy. A 35-year-old man with nephrotic syndrome and HBV antigens received a 24-week course of IFN-a. At the end of therapy there was an elevation in the level of plasma aminotransferase and an increase in proteinuria, which were followed by antigen/antibody seroconversion. This "flare-up" before seroconversion suggests an increase in disease activity in the liver and kidney, demonstrating in vivo HBV involvement in MGN.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License