期刊论文详细信息
Sao Paulo Medical Journal
How should PCNA be assessed? Total of stained cells or only the most intensely stained ones?
Claudio Kemp1  Vânia Nosé Alberti1  Geraldo Rodrigues De Lima1  Filomena Marino De Carvalho1 
[1] ,Universidade Federal de São PauloSão Paulo,Brazil
关键词: Breast Cancer;    Prognostic Factor;    Proliferating cell nuclear antigen (PCNA/cyclin);   
DOI  :  10.1590/S1516-31801998000200005
来源: SciELO
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【 摘 要 】

OBJECTIVE: This study aimed to analyse whether a marker of proliferative activity (PCNA) could provide a prognosis of tumor evolution and to determine whether different interpretation criteria could alter the results. METHOD: The presence of PCNA in 59 patients of state II (T2 NO,1 MO) mammary carcinoma was determined. RESULT: Numerical proportions of total and intensely stained cells were established. These data were compared with anatomopathological parameters. A significant association between higher cyclin values and worse histological and nuclear grading was encountered, particularly in patients with a "negative axilla" using the PCNA index. Cyclin values were not significant in relation to any parameters when indices from the intensely stained cells were considered exclusively. CONCLUSION: Higher nuclear (NG3) and histological (HGIII) grading, associated with a high PCNA index (>50), distinguish high-risk patients, and it is more appropriate considering all the stained cells as representative of PCNA indices, thus reflecting tumor aggressiveness.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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