Platelet aggregation and lipoprotein levels in a patient with familial hypercholescholesterolemia after selective LDL-apheresis

Sao Paulo Medical Journal

Madalena Nunes Da Silva Pares¹  Elbio Antonio D'amico¹  José Mauro Kutner¹  Dalton De Alencar Fischer Chamone¹  Sergio Paulo Bydlowski¹ 

[1] ,Fundação Pró-Sangue Hemocentro de São Paulo Research and Molecular Biology Division

关键词: Platelet aggregation;    Familial hypercholesterolemia;    LDL-apheresis;   

DOI  :  10.1590/S1516-31801997000300009

来源: SciELO

【 摘 要 】

Platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after aphereis selective for low-density lipoprotein (LDL), a lipid-lowering procedure.This treatment reduced plasmatic levels of total and LDL-cholesterol, apo B, and triglyceride. Increased platelet aggregation was reduced immediately after the apheresis in whole blood as well as in platelet-rich plasma. However, aggregation in washed platelets remained unchanged after LDL-apheresis. In conclusion, in this patient reduction of LDL-cholesterol improved platelet function in the very short term.

【 授权许可】

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