Preparation of hybrid biomaterials for bone tissue engineering

Materials Research

Vilma Conceição Costa¹  Hermes Souza Costa¹  Wander Luiz Vasconcelos¹  Marivalda De Magalhães Pereira¹  Rodrigo Lambert Oréfice¹  Herman Sander Mansur¹ 

[1] ,Universidade Federal de Minas Gerais Departamento de Engenharia Metalúrgica e Materiais Belo Horizonte MG ,Brazil

关键词: biomaterial;    bioceramics;    polymer;    tissue engineering;    hybrids;    sol-gel;    bioglass;   

DOI  :  10.1590/S1516-14392007000100006

来源: SciELO

【 摘 要 】

Tissue engineering has evolved from the use of biomaterials for bone substitution that fulfill the clinical demands of biocompatibility, biodegradability, non-immunogeneity, structural strength and porosity. Porous scaffolds have been developed in many forms and materials, but few reached the need of adequate physical, biological and mechanical properties. In the present paper we report the preparation of hybrid porous polyvinyl alcohol (PVA)/bioactive glass through the sol-gel route, using partially and fully hydrolyzed polyvinyl alcohol, and perform structural characterization. Hybrids containing PVA and bioactive glass with composition 58SiO2-33CaO-9P2O5 were synthesized by foaming a mixture of polymer solution and bioactive glass sol-gel precursor solution. Sol-gel solution was prepared from mixing tetraethoxysilane (TEOS), triethylphosphate (TEP), and calcium chloride as chemical precursors. The hybrid composites obtained after aging and drying at low temperature were chemically and morphologically characterized through infrared spectroscopy and scanning electron microscopy. The degree of hydrolysis of PVA, concentration of PVA solution and different PVA-bioglass composition ratios affect the synthesis procedure. Synthesis parameters must be very well combined in order to allow foaming and gelation. The hybrid scaffolds obtained exhibited macroporous structure with pore size varying from 50 to 600 µm.

【 授权许可】

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