Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study)

Revista Brasileira de Epidemiologia

Vivian C. Luft¹  Mark Pereira¹  James S. Pankow¹  Christie Ballantyne¹  David Couper¹  Gerardo Heiss¹  Bruce B. Duncan¹ 

关键词: Diabetes;    Retinol-Binding Proteins;    RBP4 protein;    human;    Epide­miologic Studies;    Diabetes;    Proteína car­readora de retinol;    RBP4;    Estudo epide­miológico;   

DOI  :  10.1590/S1415-790X2013000200014

来源: SciELO

【 摘 要 】

Background: Retinol binding protein 4 (RBP4) has been described as a link between impaired glucose uptake in adipocytes and systemic insulin sensitivity. Objective: To determine whether RBP4 fasting levels predict the development of type 2 diabetes. Methods: Using a case-cohort design, we followed 543 middle-aged individuals who developed diabetes and 537 who did not over ~9 years within the population-based Atherosclerosis Risk in Communities Study. Weighted Cox proportional hazards analyses permitted statistical inference of the RBP4 – incident diabetes associations to the entire cohort. Results: Women in the highest tertile of RBP4 presented greater risk of developing diabetes (HR = 1.74; 95%CI 1.03 – 2.94) in analyses adjusted for age, ethnicity, study center, parental history of diabetes, hypertension, glomerular filtration rate, body mass index, waist-hip ratio, nonesterified fatty acids, adiponectin, leptin, triglycerides and HDL-C. When additionally adjusted for fasting insulin, this association’s significance became borderline (HR = 1.68; 95%CI 1.00 – 2.82). No association between RBP4 levels and incident diabetes was found in men. Conclusion: These findings suggest that RBP4 levels may be directly involved in the pathogenesis of type 2 diabetes in women.

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