Initial antiretroviral therapy in a 20-year observational cohort of patients followed at a reference center in the City of São Paulo, Brazil

Revista Brasileira de Epidemiologia

Emily A. C. Ruiz²  Marta Ramalho²  Mariza V. Tancredi²  Jean P. Moatti¹  Ana L. C. Monteiro²  Mylva Fonsi²  Julien Chauveau¹ 

[1] ,São Paulo STD

关键词: Antiretroviral treatment;    Treatment;    HIV;    Aids;    Epidemiology;    ART;    Tratamento antiretroviral;    Tratamento;    HIV;    Aids;    Epidemiologia;    ARV;   

DOI  :  10.1590/S1415-790X2011000100008

来源: SciELO

【 摘 要 】

INTRODUCTION: Production and free universal access to ART for patients with HIV/Aids were responsible for a major fall in morbidity-mortality in Brazil. OBJECTIVE: To describe antiretroviral treatment at the São Paulo STD/Aids Training and Reference Center. METHODS: Cross-sectional analysis of the characteristics of the first treatment with antiretroviral drugs of a retrospective cohort of patients 13 years and over, enrolled at the Reference Center, 1985-2005, described by frequency tables and graphs. RESULTS: 4,191 patients were described. The most frequent initiation period was 1999-2003; 82.7% of patients were treatment naïve. Monotherapy prevailed until 1995, the peak of double therapy was 1996-98, and 1999-2005 was characterized by triple therapy. Regarding triple therapy, regimens with protease inhibitors accounted for 1,462 (34.9%) of all first prescriptions. The combination AZT, 3TC and EFV was the most frequently prescribed regimen (47.4%) in 2005. CONCLUSIONS: This descriptive study may enable more in depth analyses on the factors involved in the treatment patients with HIV/AIDS.

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