Initial antiretroviral therapy in a 20-year observational cohort of patients followed at a reference center in the City of São Paulo, Brazil

Revista Brasileira de Epidemiologia

Monteiro, Ana L. C.¹  Chauveau, Julien²  Ramalho, Marta¹  Tancredi, Mariza V.¹  Ruiz, Emily A. C.¹  Fonsi, Mylva¹  Moatti, Jean P.² 

[1] São Paulo STD;Aix Marseilles Université, Marseilles, France

关键词: Antiretroviral treatment;    Treatment;    HIV;    Aids;    Epidemiology;    ART;   

DOI  :  10.1590/S1415-790X2011000100008

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

INTRODUCTION:Production and free universal access to ART for patients with HIV/Aids wereresponsible for a major fall in morbidity-mortality in Brazil.
OBJECTIVE: To describe antiretroviral treatment at the São PauloSTD/Aids Training and Reference Center.
METHODS: Cross-sectional analysis of the characteristics of the firsttreatment with antiretroviral drugs of a retrospective cohort of patients 13years and over, enrolled at the Reference Center, 1985-2005, described by frequencytables and graphs.
RESULTS: 4,191 patients were described. The most frequent initiationperiod was 1999-2003; 82.7% of patients were treatment naïve. Monotherapyprevailed until 1995, the peak of double therapy was 1996-98, and 1999-2005was characterized by triple therapy. Regarding triple therapy, regimens withprotease inhibitors accounted for 1,462 (34.9%) of all first prescriptions.The combination AZT, 3TC and EFV was the most frequently prescribed regimen(47.4%) in 2005.
CONCLUSIONS: This descriptive study may enable more in depth analyseson the factors involved in the treatment patients with HIV/AIDS.

【 授权许可】

CC BY