Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital

Revista de Nutrição

Mohammad Reza Oladi²  Javad Behravan¹  Mitra Hassani¹  Jamal Kassaeian¹  Amirhossein Sahebkar²  Shima Tavallaie¹  Roghayeh Paydar¹  Hamidreza Saber¹  Habib Allah Esmaeili¹  Mohsen Azimi-nezhad²  Gordon Ferns¹  Majid Ghayour-mobarhan¹ 

[1],Mashhad University of Medical Sciences Cardiovascular Research Center Mashhad,Iran

关键词: Body mass index;    Glucokinase;    Metabolic syndrome;    Obesity;    Single nucleotide polymorphism;    Índice de massa corporal;    Glucoquinase;    Síndrome metabólica;    Obesidade;    Polimorfismo de nucleotídeo único;   

DOI  :  10.1590/S1415-52732012000400006

来源: SciELO

【 摘 要 】

OBJECTIVE: A -30G>A single nucleotide polymorphism in the promoter region of the glucokinase gene has been previously associated with obesity, insulin resistance and diabetes. The present study aimed to evaluate the association of this polymorphism with obesity and its comorbidities in a population from Northeast Iran. METHODS: Five hundred and forty-two subjects aged 18 to 65 years were included in the study and divided into normal (BMI<25, n=220), overweight (2530, n=187) groups. All subjects were genotyped for the -30G>A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The genotypes and allele frequencies of the three groups did not differ significantly (p>0.05). When the study population was categorized according to diabetes mellitus, hyperlipidemia, hypertension and metabolic syndrome status, no significant difference in -30G>A genotypes and alleles was found between the subgroups with and without these disorders (p>0.05), apart from a significantly higher frequency of the G allele in the hyperlipidemic vs. non-hyperlipidemic subgroup (p<0.05). CONCLUSION: The findings of the present study do not support an association between the -30G>A polymorphism and high body mass index in the Iranian population.

【 授权许可】

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