Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population

Genetics and Molecular Biology

Mateusz Kurzawski¹  Anna Wajda¹  Damian Malinowski¹  Anna Kazienko¹  Rafal Kurzawa¹  Marek Drozdzik¹ 

关键词: MTHFR;    MTR;    MTRR;    polymorphism;    infertility;   

DOI  :  10.1590/S1415-475738120140179

来源: SciELO

【 摘 要 】

Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.

【 授权许可】

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