Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk?From a Case-Control to a Meta-Analysis of 30,327 Subjects

International Journal of Molecular Sciences

Jian Wei¹  Yi-Nuo Wang²  Yan-Xun Wang²  Gui-Fan Sun³  Shu-Jun Fan³  Quan-Mei Zheng³  Bo-Yi Yang³  Miao He³  Xue-Yuan Zhi³  Da Wang³ 

[1] Brain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, China;Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China;Research Center of Environment and Non-Communicable Disease, School of Public Health,China Medical University, Shenyang 110013, China;

关键词: MTHFR;    MTRR;    overweight;    obesity;    polymorphism;   

DOI  :  10.3390/ijms160611849

来源: DOAJ

【 摘 要 】

Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.

【 授权许可】

Unknown