Gender-dependent association of HSD11B1 single nucleotide polymorphisms with glucose and HDL-C levels

Genetics and Molecular Biology

Luciane Viater Turek²  Neiva Leite¹  Ricardo Lehtonen Rodrigues Souza²  Jovana Karoline Lima²  Gerusa Eisfeld Milano¹  Luciana Da Silva Timossi¹  Ana Claudia Vecchi Osiecki¹  Raul Osiecki¹  Lupe Furtado Alle² 

[1],Universidade Federal de Paraná Departamento de Genética Curitiba PR ,Brazil

关键词: HSD11B1 gene;    men;    metabolism;    metabolic syndrome;    women;   

DOI  :  10.1590/S1415-47572014000400003

来源: SciELO

【 摘 要 】

In this study, we investigated the influence of two SNPs (rs846910 and rs12086634) of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1), the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of both sexes from southern Brazil. The HSD11B1 gene variants were genotyped using the TaqMan SNP genotyping assay. Glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were measured by standard automated methods. Significant results were found in women, with carriers of the G allele of SNP rs12086634 having higher glucose levels than non-carriers. Carriers of the A allele of SNP rs846910 had higher levels of HDL-cholesterol. The involvement of both polymorphisms as independent factors in determining the levels of glucose and HDL-cholesterol was confirmed by multiple regression analysis (β = 0.19 ± 0.09, p = 0.03 and β = 0.22 ± 0.10, p = 0.03, respectively). Our findings suggest that the HSD11B1SNPs studied may indirectly influence glucose and HDL-cholesterol metabolism in women, possibly through down-regulation of the HSD11B1 gene by estrogen.

【 授权许可】

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